Calcichew d3 forte инструкция 500 mg 20 mg
Serum electrolytes, renal function and diuresis must be monitored. In severe cases, ECG and CVP should be followed. Vitamin D3 increases the intestinal absorption of calcium.
Calcichew-D3 Forte Chewable Tablets contain aspartame E, a source of phenylalanine which may be harmful for people with phenylketonuria. Calcichew-D3 Forte Chewable Tablets contain sorbitol Eisomalt E and sucrose. Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption Calcichew d3 forte инструкция 500 mg 20 mg sucrase-isomaltase insufficiency should not take this medicine.
Calcichew-D3 Forte Chewable Tablets should be prescribed with caution to patients suffering from sarcoidosis because of the risk of increased metabolism of vitamin D3 to its active form. These patients should be monitored with regard to the calcium content in serum and urine. Calcichew-D3 Forte Chewable Tablets should be used with caution in immobilised patients with osteoporosis due to the Calcichew d3 forte инструкция 500 mg 20 mg risk of hypercalcaemia.
Quinolone antibiotics should be taken two hours before or six hours after intake of calcium. If a bisphosphonate is used concomitantly, this preparation should be administered at least one hour before the intake of Calcichew-D3 Forte Chewable Tablets since gastrointestinal absorption may be reduced. Calcium salts may decrease the absorption of iron, zinc and strontium ranelate. Consequently, iron, zinc Calcichew d3 forte инструкция 500 mg 20 mg strontium ranelate preparations should be taken at least two hours before or after Calcichew-D3 Forte Chewable Tablets.
Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www. Overdose can lead to hypercalcaemia and hypervitaminosis D. Symptoms of hypercalcaemia may include anorexia, thirst, nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, mental disturbances, polydipsia, polyuria, bone pain, nephrocalcinosis, nephrolithiasis and in severe cases, cardiac arrhythmias.
Calcichew-D3 Forte Chewable Tablets have no known influence on the ability to drive and use machines. Adverse reactions are listed below, by system organ class and frequency. Not known: Hypersensitivity reactions such as angio-oedema or laryngeal oedema. Metabolism and nutrition disorders. Uncommon: Hypercalcaemia and hypercalciuria.
The tablets should be chewed or sucked. During long-term treatment, serum calcium levels should be Calcichew d3 forte инструкция 500 mg 20 mg and renal function should be monitored through measurements of serum creatinine. Monitoring is especially important in patients on concomitant treatment with cardiac glycosides or diuretics see section 4. In case of hypercalcaemia or signs of impaired renal function the dose should be reduced or the treatment discontinued.
Studies in animals have shown reproductive toxicity with high doses of vitamin D see section 5. In pregnant women, overdoses of calcium and vitamin D should be avoided as permanent hypercalcaemia has been related to adverse effects on the developing foetus. There are no indications that vitamin D at therapeutic doses is teratogenic in humans. Calcichew-D3 Forte Chewable Tablets can be used during breast-feeding. Calcium and vitamin D3 pass into breast milk. This should be considered when giving additional vitamin D to the child.
Calcichew-D3 Forte Chewable Tablets should be used with caution in patients with hypercalcaemia or signs of impaired renal function and the effect on calcium and phosphate levels should be monitored. The risk of soft tissue calcification should be taken into account. In patients with severe renal insufficiency, vitamin D in the form of colecalciferol is not metabolised normally and other forms of vitamin D should be used see section 4. In these patients serum calcium levels should be followed and renal function should be monitored.
Calcichew-D3 Forte Chewable Tablets are not intended for use in children. No dose adjustment is required. Calcichew-D3 Forte Chewable Tablets should not be used in Calcichew d3 forte инструкция 500 mg 20 mg with severe renal impairment see section 4.
Administration of calcium and vitamin D3 counteracts the increase of parathyroid hormone PTHwhich is caused by calcium deficiency and which causes increased bone resorption. A clinical study of institutionalised patients suffering from vitamin D deficiency indicated that a daily intake of two tablets of Calcichew-D3 Forte chewable tablets for six months normalised the value of the hydroxylated metabolite of vitamin D3 and reduced secondary hyperparathyroidism and alkaline phosphatases.
Vitamin D3, which is not metabolised, is stored in adipose and muscle tissues. Elimination: Vitamin D3 is excreted in faeces and urine. At doses far higher than the human therapeutic range teratogenicity has been observed in animal studies. There is no further information of relevance to the safety assessment in addition to what is stated in other parts of the SmPC.
Milk-alkali syndrome may occur in patients who ingest large amounts of calcium and absorbable alkali. Treatment is essentially symptomatic and supportive. The treatment with calcium must be discontinued. Treatment with thiazide diuretics and cardiac glycosides must also be discontinued see section 4. Treatment: rehydration, and, according to severity Calcichew d3 forte инструкция 500 mg 20 mg hypercalcaemia, isolated or combined treatment with loop diuretics, bisphosphonates, calcitonin and corticosteroids should Calcichew d3 forte инструкция 500 mg 20 mg considered.
Very rare: Milk-alkali syndrome frequent urge to urinate; continuing headache; continuing loss of appetite; nausea or vomiting; unusual tiredness or weakness; hypercalcaemia, alkalosis and renal impairment. Seen usually only in overdose see section 4. Rare: Constipation, dyspepsia, flatulence, nausea, abdominal pain and diarrhoea. Skin and subcutaneous disorders. Rare: Pruritus, rash and urticaria. Reporting of suspected adverse reactions. Reporting suspected adverse reactions after authorisation of the medicinal product is important.
Extreme hypercalcaemia may result in coma and death. Persistently high calcium levels may lead to irreversible renal damage and soft tissue calcification.
It is then further converted in the kidneys to the active form 1,dihydroxycholecalciferol; 1,dihydroxycholecalciferol is the metabolite responsible for increasing calcium absorption.
Patients should be monitored with regard to electrocardiogram ECG and serum calcium levels. The efficacy of levothyroxine can be reduced by the concurrent use of calcium, due to decreased levothyroxine absorption. Administration of calcium and levothyroxine should be separated by at least four hours. The absorption of quinolone antibiotics may be impaired if administered concomitantly with calcium.
Elimination: Calcium is eliminated through faeces, urine and sweat. Renal excretion Calcichew d3 forte инструкция 500 mg 20 mg on glomerular filtration and calcium tubular reabsorption. Absorption: Vitamin D is easily absorbed in the small intestine. Distribution and biotransformation: Colecalciferol and its metabolites circulate in the blood bound to a specific globulin. Colecalciferol is converted in the liver by hydroxylation to hydroxycholecalciferol.
Calcium carbonate may interfere with the absorption of concomitantly administered tetracycline preparations. For this reason, tetracycline preparations should be administered at least two hours before, or four to six hours after, oral intake of calcium carbonate. Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D.
Thiazide diuretics reduce the urinary excretion of calcium. Due to increased risk of hypercalcaemia, serum calcium should be regularly monitored during concomitant use of thiazide diuretics.
Treatment with orlistat may potentially impair the absorption of fat-soluble vitamins e. Calcichew-D3 Forte Chewable Tablets can be used during pregnancy, in case of a calcium and vitamin D deficiency. During pregnancy the daily intake should not exceed mg calcium and IU vitamin D.
19.06.2017 15:35:23 Похотью, он не пропускает ни одну барышню, проходящую мимо, дрожа.
20.06.2017 22:38:40 Между отправками(Timer), с ним будьте осторожней.
20.06.2017 13:11:58 Совершает ошибку и ставит устаканилась возможность разводить попрактикуйтесь на специально оборудованном автодроме, водите автомобиль в режиме экзамена.